Discovering new interventions in immuno-regulatory pathways to control infectious and non-infectious inflammatory diseases
Pathogens have the ability to control various facets of immunological networks. Parasites, for example, can influence the balance between anti- and pro-inflammatory responses (immunosuppression and immunotolerance) not only in their host, but in 'bystander' pathogens as well. Similarly, many viruses subvert the immune response to their own benefit.
ithree institute's work in this area will allow us to identify new entry points into the immune system networks that could be controlled by drug intervention, and utilise successful viral strategies as models for developing new anti-inflammatory agents.
Since different pathogens influence different immunological pathways ithree institute resources place us in a unique position to exploit this area of research. We expect to find applications to other major human immune disorders such as asthma and arthritis.